" /> Liarozole - CISMeF





Preferred Label : Liarozole;

NCIt synonyms : R-61405; 1H-Benzimidazole, 5-((3-chlorophenyl)-1H-imidazol-1-ylmethyl)-;

NCIt definition : An orally-active benzimidazole derivative with potential antineoplastic activity. As a retinoic acid metabolism blocking agent, liarozole inhibits cytochrome P450-dependent all-trans-retinoic acid (ATRA)-4-hydroxylase, resulting in an increase in endogenous ATRA production, inhibition of cell proliferation, and induction of cell differentiation. This agent also inhibits aromatase, the enzyme that catalyzes the final, rate-limiting step in estrogen biosynthesis.;

Alternative definition : NCI-GLOSS: An anticancer drug that promotes differentiation by increasing the levels of retinoic acid within the tumor.;

UNII : K0Q29TGV9Y;

InChIKey : UGFHIPBXIWJXNA-UHFFFAOYSA-N;

CAS number : 115575-11-6; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 115575-11-6 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Liazal;

Molecule name : R 75251;

Chemical formula : C17H13ClN4;

Codes from synonyms : 31430; CDR0000045752;

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12/05/2024


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