" /> Liarozole Hydrochloride - CISMeF





Preferred Label : Liarozole Hydrochloride;

NCIt synonyms : Liarozole HCl; 1H-Benzimidazole, 5-((3-chlorophenyl)-1H-imidazol-1-ylmethyl)-, Monohydrochloride, ( -)-; ( -)-5-(m-Chloro-alpha-imidazol-1-ylbenzyl)benzimidazole Monohydrochloride;

NCIt definition : The fumarate salt of an orally-active benzimidazole derivative with potential antineoplastic activity. As a retinoic acid metabolism blocking agent (RAMBA), liarozole inhibits cytochrome P450-dependent all-trans-retinoic acid (ATRA)-4-hydroxylase, resulting in an increase in endogenous ATRA production, inhibition of cell proliferation, and induction of cell differentiation. This agent also inhibits aromatase, the enzyme that catalyzes the final, rate-limiting step in estrogen biosynthesis.;

UNII : 29T7S2IB97;

InChIKey : OTSZCHORPMQCBZ-UHFFFAOYSA-N;

CAS number : 145858-50-0; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 145858-50-0 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : R 75251;

Chemical formula : C17H13ClN4.HCl;

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12/05/2024


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