Liarozole Fumarate

Preferred Label : Liarozole Fumarate;

NCIt synonyms : ( -)-5-(m-Chloro-alpha-imidazol-1-ylbenzyl)benzimidazole Fumarate (2:3); 1H-Benzimidazole, 5-((3-chlorophenyl)-1H-imidazol-1-ylmethyl)-, ( -)-, (E)-2-butenedioate (2:3);

NCIt definition : The orally active fumarate salt of the benzimidazole derivative liarozole with potential antineoplastic activity. As a retinoic acid metabolism blocking agent (RAMBA), liarozole inhibits cytochrome P450-dependent all-trans-retinoic acid (ATRA)-4-hydroxylase, resulting in an increase in endogenous ATRA production, inhibition of cell proliferation, and induction of cell differentiation. This agent also inhibits aromatase, the enzyme that catalyzes the final, rate-limiting step in estrogen biosynthesis.;

UNII : 91W7VLK7J3;

InChIKey : IDTXURCCJVODEQ-VQYXCCSOSA-N;

CAS number : 145858-52-2;

Molecule name : R85246;

Chemical formula : 2C17H13ClN4.3C4H4O4;

Details

Origin ID

C1524;

UMLS CUI

C0245820;

Automatic exact mappings (from CISMeF team)
- liarozole [MeSH Supplementary Concept]
Currated CISMeF NLP mapping
- liarozole fumarate [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- liarozole fumarate [MeSH concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_free_acid_or_base_form
- Liarozole [NCIt concept]
is_salt_form_of
- Liarozole [NCIt concept]

Keyword's position in hierarchy(ies) :

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