NCIt definition : The orally active fumarate salt of the benzimidazole derivative liarozole with potential
antineoplastic activity. As a retinoic acid metabolism blocking agent (RAMBA), liarozole
inhibits cytochrome P450-dependent all-trans-retinoic acid (ATRA)-4-hydroxylase, resulting
in an increase in endogenous ATRA production, inhibition of cell proliferation, and
induction of cell differentiation. This agent also inhibits aromatase, the enzyme
that catalyzes the final, rate-limiting step in estrogen biosynthesis.;
UNII : 91W7VLK7J3;
InChIKey : IDTXURCCJVODEQ-VQYXCCSOSA-N;
CAS number : 145858-52-2; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 145858-52-2
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;