Beta-2-Glycoprotein 1

Preferred Label : Beta-2-Glycoprotein 1;

NCIt synonyms : Apolipoprotein H; B2GPI; Beta(2)GPI; Activated Protein C-Binding Protein; Apo-H; Anticardiolipin Cofactor; APC Inhibitor; Beta-2-Glycoprotein I; APOH;

NCIt related terms : BETA-2 GLYCOPROTEIN 1;

NCIt definition : Beta-2-glycoprotein 1 (345 aa, 38 kDa) is encoded by the human APOH gene. This protein is involved in binding to phospholipids, glycosaminoglycans and other negatively charged substances.;

Alternative definition : CDISC: An antigen of the cardiolipin-binding protein encoded by the APOH gene. It can be considered as an autoantigen and is commonly associated with the autoimmune diseases antiphospholipid syndrome and systemic rheumatic diseases like systemic lupus erythematosus.;

NCIt note : Beta-2-glycoprotein 1 may be a required cofactor for anionic phospholipid binding by the antiphospholipid autoantibodies found in sera of many patients with lupus and primary antiphospholipid syndrome. (EntrezGene);

NCI Metathesaurus CUI : CL524123;

Détails

Origin ID

C142155;

UMLS CUI

C4553380;

Automatic exact mappings (from CISMeF team)
- Apolipoprotein h [OMIM gene]
- apolipoprotein H [HGNC gene]
- negative regulation of ubiquitin-protein transferase activity [GO term]
Currated CISMeF NLP mapping
- Apolipoprotein H (substance) [SNOMED CT concept]
- Beta 2 glycoprotein 1 [LOINC component]
- apolipoprotein h [SNOMED Notion]
- beta 2-Glycoprotein I [MeSH concept]
- beta 2-Glycoprotein I [MeSH Descriptor]
OMIM relation
- Apolipoprotein h [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
concept_is_in_subset
- CDISC SDTM Binding Agent for Immunogenicity Tests Terminology [NCIt concept]
- CDISC SDTM Terminology [NCIt concept]
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- Clinical Data Interchange Standards Consortium Terminology [NCIt concept]
gene_encodes_gene_product
- APOH Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Sushi Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Coagulation Process [NCIt concept]
- Heparin Binding [NCIt concept]
- Ligand Binding [NCIt concept]
- Phospholipid Binding [NCIt concept]
is_target
- Bavituximab [NCIt concept]

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