NCIt definition : Beta-2-glycoprotein 1 (345 aa, 38 kDa) is encoded by the human APOH gene. This protein
is involved in binding to phospholipids, glycosaminoglycans and other negatively charged
substances.;
Alternative definition : CDISC: An antigen of the cardiolipin-binding protein encoded by the APOH gene. It
can be considered as an autoantigen and is commonly associated with the autoimmune
diseases antiphospholipid syndrome and systemic rheumatic diseases like systemic lupus
erythematosus.;
NCIt note : Beta-2-glycoprotein 1 may be a required cofactor for anionic phospholipid binding
by the antiphospholipid autoantibodies found in sera of many patients with lupus and
primary antiphospholipid syndrome. (EntrezGene);