Zanubrutinib - CISMeF

Preferred Label : Zanubrutinib;

NCIt synonyms : (S)-7-(1-acryloylpiperidin-4-yl)-2-(4-phenoxyphenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyrimidine-3-carboxamide;

NCIt definition : An inhibitor of Bruton's tyrosine kinase (BTK) with potential antineoplastic activity. Upon administration, zanubrutinib inhibits the activity of BTK and prevents the activation of the B-cell antigen receptor (BCR) signaling pathway. This prevents both B-cell activation and BTK-mediated activation of downstream survival pathways, which leads to the inhibition of the growth of malignant B-cells that overexpress BTK. BTK, a member of the Src-related BTK/Tec family of cytoplasmic tyrosine kinases, is overexpressed in B-cell malignancies; it plays an important role in B-lymphocyte development, activation, signaling, proliferation and survival.;

UNII : AG9MHG098Z;

InChIKey : RNOAOAWBMHREKO-QFIPXVFZSA-N;

CAS number : 1691249-45-2;

Drug name : Brukinsa;

Molecule name : BTK-InhB; BGB-3111; BGB 3111;

Codes from synonyms : 50482;

Details

Origin ID

C141428;

UMLS CUI

C4683810;

Currated CISMeF NLP mapping
- Zanubrutinib [SMS substance]
- Zanubrutinib (substance) [SNOMED CT concept]
- zanubrutinib [MeSH Supplementary Concept]
- zanubrutinib [MeSH concept]
Manual BTNT mappings - CISMeF
- zanubrutinib [ATC Code]
See also inter- (CISMeF)
- Product containing zanubrutinib (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Product containing zanubrutinib (medicinal product) [SNOMED CT concept]
- Zanubrutinib (substance) [SNOMED CT concept]
- zanubrutinib [MeSH Supplementary Concept]
- zanubrutinib [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
- NCIt COVID-19 Agent Terminology [NCIt concept]
- NCIt COVID-19 Terminology [NCIt concept]
has_target
- Tyrosine-Protein Kinase BTK [NCIt concept]
is_component_of_chemotherapy_regimen
- Obinutuzumab/Venetoclax/Zanubrutinib Regimen [NCIt concept]
- Obinutuzumab/Zanubrutinib Regimen [NCIt concept]
- Zanubrutinib Regimen [NCIt concept]

Keyword's position in hierarchy(ies) :

Main resources

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