Preferred Label : Armadillo Repeat;
NCIt synonyms : Armadillo/Beta-Catenin-Like Repeat; Beta-Catenin Binding Repeat; Beta-Catenin-Binding Domain; ARM Domain; Beta-Catenin-Like Repeat; ARM Repeat;
NCIt definition : Identified in over 240 functionally diverse proteins from yeast to man, ARM Repeats
are approximately 40-amino acids long and composed of two longer anti-parallel helices
(H2 and H3) that follow a perpendicular short helix (H1). Tandem repeats form a right-handed
superhelix (3 helixes per unit); tight repeat packing creates a cylindrical hydrophobic
core throughout the structure. Lined by highly conserved residues, the positively
charged groove of the superhelix appears to mediate interaction with acidic surfaces
of target proteins. Despite amino acid variability, ARM repeat structures are highly
conserved. Though involved in protein-protein interactions, no common features among
target proteins have been identified. ARM repeats have a common phylogenetic origin
with the HEAT repeat; both contain seven highly conserved hydrophobic residues.;
Origin ID : C14101;
UMLS CUI : C1510939;
Semantic type(s)
- is_structural_domain_or_motif_of_gene_product
