Aldose Reductase

Preferred Label : Aldose Reductase;

NCIt synonyms : Aldehyde Reductase 1; AR; AKR1B1; Low Km Aldose Reductase; EC 1.1.1.21; Aldehyde Reductase; Aldo-Keto Reductase Family 1 Member B1; Lii5-2 CTCL Tumor Antigen;

NCIt definition : Aldose reductase (316 aa, 36 kDa) is encoded by the human AKR1B1 gene. This protein plays a role in glucose metabolism.;

NCIt note : Aldose reductase catalyzes the reduction of glucose to sorbitol, which can cause complications in diabetic patients and can be treated with the noncompetitive, reversible aldose reductase inhibitor epalrestat.;

Details

Origin ID

C133811;

UMLS CUI

C1436327;

Automatic exact mappings (from CISMeF team)
- Aldehyde reductase (substance) [SNOMED CT concept]
- Aldo-keto reductase family 1, member a1 [OMIM gene]
- Aldo-keto reductase family 1, member b1 [OMIM gene]
- Androgen receptor [OMIM gene]
- Aortic valve insufficiency [ICD-11 Category]
- Arising in (attribute) [SNOMED CT concept]
- Carbonyl reductase (reduced nicotinamide adenine dinucleotide phosphate) (substance) [SNOMED CT concept]
- aldehyde reductase [MeSH Descriptor]
- aldehyde reductase [SNOMED Notion]
- aldehyde reductase [MeSH concept]
- aldo-keto reductase family 1 member A1 [HGNC gene]
- aldo-keto reductase family 1 member B [HGNC gene]
- androgen receptor [ORDO Gene]
- carbonyl reductase (NADPH) activity [GO term]
- drug evaluation [MeSH Descriptor]
OMIM relation
- Aldo-keto reductase family 1, member b1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- AKR1B1 protein, human [MeSH Supplementary Concept]
- AKR1B1 protein, human [MeSH concept]
gene_encodes_gene_product
- AKR1B1 Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Oxidoreductase Gene [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Fructose and Mannose Metabolism Pathway [NCIt concept]
- Galactose Metabolism Pathway [NCIt concept]
- Glycerolipid Metabolism Pathway [NCIt concept]
- Pentose and Glucuronate Interconversions Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Carbohydrate Metabolic Process [NCIt concept]
- Oxidation [NCIt concept]
- Oxidation/Reduction [NCIt concept]
- Steroid Metabolic Process [NCIt concept]

Keyword's position in hierarchy(ies) :

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