Helix-Loop-Helix Domain

Preferred Label : Helix-Loop-Helix Domain;

NCIt synonyms : HLH Domain; HLH Motif; Helix-Loop-Helix Motif;

NCIt definition : In transcription regulators of cell cycle control, cell determination, and cell differentiation, the conserved HLH (Helix-Loop-Helix) Domain of 40-50 amino acids forms amphipathic helixes between a variable loop. HLHs typically mediate homo- or heterodimerization through interactions with self or other motifs to activate or inactivate trans-activating function. The N-helix often contains DNA-interacting basic residues; the C-helix typically contains characteristically spaced hydrophobic residues. An adjacent basic region of 15 amino acids in most HLH proteins binds to DNA. Basic (b)HLH proteins bind variants of the 'CANNTG' E-box. Proteins lacking the basic domain act as inhibitors, failing to bind DNA. bHLH proteins exhibit specific dimerization partner combinations. In calcium-binding proteins, certain invariant hydrophilic loop residues in the HLH motif bind calcium. (NCI);

Details

Origin ID

C13313;

UMLS CUI

C0206678;

Currated CISMeF NLP mapping
- Helix-Loop-Helix motifs [MeSH concept]
- helix-loop-helix motifs [MeSH Descriptor]
Semantic type(s)
- Spatial Concept [UMLS semantic type]
UMLS correspondences (same concept)
- Helix-Loop-Helix motifs [MeSH concept]
- helix-loop-helix motifs [MeSH Descriptor]
is_structural_domain_or_motif_of_gene_product
- Breast Cancer Anti-Estrogen Resistance Protein 1 [NCIt concept]

Keyword's position in hierarchy(ies) :

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