ZFTA/RELA Fusion Protein

Preferred Label : ZFTA/RELA Fusion Protein;

NCIt synonyms : C11orf95-RELA Fusion Protein; Uncharacterized Protein C11orf95/Transcription Factor p65 Fusion Protein; Uncharacterized Protein C11orf95/NF-Kappa B p65 Fusion Protein; Zinc Finger Translocation-Associated Protein/NF-Kappa B p65 Fusion Protein; C11orf95/RELA Fusion Protein; ZFTA-RELA Fusion Protein; Zinc Finger Translocation-Associated Protein-NF-Kappa B p65 Fusion Protein; ZFTA::RELA Fusion Protein;

NCIt definition : A fusion protein encoded by the ZFTA/RELA fusion gene. This protein is comprised of the N-terminal domain of uncharacterized protein C11orf95 fused to most of the transcription factor p65 protein, including the transactivation domain.;

NCIt note : Unlike transcription factor p65, which is conditionally sequestered in the cytoplasm by IkappaB, the C11orf95/RELA fusion protein is preferentially localized to the nucleus where it acts as a constitutive activator of NF-kappa-B-dependent gene transcription.;

NCI Metathesaurus CUI : CL512100;

PubMed : 24553141;

Details

Origin ID

C129354;

UMLS CUI

C4289901;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
gene_encodes_gene_product
- Fusion Gene [NCIt concept]
- ZFTA/RELA Fusion Gene [NCIt concept]
gene_product_plays_role_in_biological_process
- Transcriptional Activation [NCIt concept]
related_to_genetic_biomarker
- RELA Gene [NCIt concept]
- ZFTA Gene [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients