Anti-VEGF/ANG2 Nanobody BI 836880

Preferred Label : Anti-VEGF/ANG2 Nanobody BI 836880;

NCIt synonyms : Bi-specific Anti-VEGF/Ang2 Nanobody BI 836880; Anti-VEGF/ANG2 BI 836880;

NCIt related terms : BI-836880;

NCIt definition : A nanobody directed against angiopoietin-2 (Ang2; ANGPT2)- and vascular endothelial growth factor (VEGF)-derived peptides, with potential antiangiogenic and antineoplastic activities. Anti-VEGF/ANG2 nanobody BI 836880 binds to Ang2 and VEGF and inhibits receptor binding; this prevents Ang2- and VEGF-mediated signaling and inhibits both tumor angiogenesis and tumor cell proliferation. Both VEGF and Ang2 are upregulated in a variety of cancer cell types and play a crucial role in angiogenesis. The nanobody is based on functional fragments of single-chain antibodies.;

UNII : IS7N1X9TSW;

CAS number : 2254603-60-4;

Molecule name : BI 836880;

NCI Metathesaurus CUI : CL503761;

Details

Origin ID

C126644;

UMLS CUI

C4287781;

Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Angiopoietin-2 [NCIt concept]
- Vascular Endothelial Growth Factor Family [NCIt concept]

Keyword's position in hierarchy(ies) :

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