Proenkephalin-A

Preferred Label : Proenkephalin-A;

NCIt synonyms : Preproenkephalin; Preproenkephalin A; Proenkephalin; Proenkephalin A; Preproenkephalin-A;

NCIt definition : Proenkephalin-A (267 aa, 31 kDa) is encoded by the human PENK gene. This protein is involved in opioid receptor signaling.;

NCIt note : Proenkephalin-A is cleaved into at least 8 potentially active peptides: Synenkephalin, Met-enkephalin, PENK(114-133), PENK(143-183), Met-enkephalin-Arg-Gly-Leu, Leu-enkephalin, PENK(237-258), and Met-enkephalin-Arg-Phe. (UniProt);

Details

Origin ID

C126496;

UMLS CUI

C4285605;

Automatic exact mappings (from CISMeF team)
- Preproenkephalin (substance) [SNOMED CT concept]
- Proenkephalin [OMIM gene]
- preproenkephalin [MeSH Supplementary Concept]
- preproenkephalin [MeSH concept]
- preproenkephalin [SNOMED Notion]
- preproenkephalin A [MeSH concept]
- proenkephalin [MeSH Supplementary Concept]
- proenkephalin [MeSH concept]
- proenkephalin [HGNC gene]
- proenkephalin A [MeSH concept]
OMIM relation
- Proenkephalin [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- PENK Gene [NCIt concept]
gene_product_has_associated_anatomy
- Membranous Cytoplasmic Organelle [NCIt concept]
- Neuron [NCIt concept]
gene_product_plays_role_in_biological_process
- Nociception [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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