Autophagy-Related Protein 13

Preferred Label : Autophagy-Related Protein 13;

NCIt synonyms : Paratarg-8; ATG13; PARATARG 8; Paraprotein Target 8;

NCIt definition : Autophagy-related protein 13 (517 aa, 57 kDa) is encoded by the human ATG13 gene. This protein plays a role in the modulation of autophagy.;

NCIt note : Autophagy-related protein 13 (ATG13) appears to be phosphorylated by phosphokinase C-zeta (PRKCZ) and dephosphorylated by phosphatase-2A (PP2A). Mutations that inactivate the PP2A catalytic subunit may be associated with hyperphosphorylation of ATG13 and may play a role in the pathogenesis of monoclonal gammopathy of unknown significance (MGUS), Waldenstrom macroglobulinemia, and multiple myeloma. (OMIM);

NCI Metathesaurus CUI : CL504720;

Details

Origin ID

C126137;

UMLS CUI

C4284300;

Automatic exact mappings (from CISMeF team)
- Autophagy-related 13 [OMIM gene]
OMIM relation
- Autophagy-related 13 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- ATG13 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytoplasm [NCIt concept]
gene_product_is_element_in_pathway
- Autophagy Regulation Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Autophagy [NCIt concept]

Keyword's position in hierarchy(ies) :

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