Preferred Label : Pegzilarginase;
NCIt synonyms : Pegylated Recombinant Arginase AEB1102; Co-ArgI-PEG;
NCIt definition : A recombinant modified form of the human enzyme arginase 1 (ARG1), in which cobalt
is substituted for manganese as a cofactor, covalently attached to polyethylene glycol
(PEG), with potential arginine degrading and antineoplastic activities. Upon intravenous
administration of pegzilarginase, ARG1 metabolizes the amino acid arginine to ornithine
and urea, thereby lowering blood arginine levels. This normalizes blood arginine levels
in patients with ARG1 deficiency and prevents hyperargininemia. This also inhibits
the proliferation of cancer cells that are dependent on extracellular arginine uptake
for their proliferation. In normal, healthy cells, arginine is synthesized intracellularly
by the enzymes ornithine transcarbamylase (OTC), argininosuccinate synthase (ASS),
and argininosuccinate lyase (ASL); thus they are not dependent on extracellular arginine
for survival. In cancer cells these enzymes are disabled; therefore, this agent may
inhibit proliferation and survival of these cells by depleting extracellular arginine.
Pegylation improves blood circulation times and cobalt substitution increases the
catalytic activity of ARG1.;
UNII : 4YV4KW88GD;
CAS number : 1659310-95-8; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1659310-95-8
alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo
G-SRS /a ;
Molecule name : AEB-1102;
NCI Metathesaurus CUI : CL503972;
Origin ID : C125143;
UMLS CUI : C4724814;
Automatic exact mappings (from CISMeF team)
- Semantic type(s)
- UMLS correspondences (same concept)
- Validated automatic mappings to BTNT
- concept_is_in_subset
