Mas-Related G-Protein Coupled Receptor Member X2

Preferred Label : Mas-Related G-Protein Coupled Receptor Member X2;

NCIt synonyms : Mas-Related G Protein-Coupled Receptor G3; Mas-Related G-Protein Coupled Receptor G3; G-Protein Coupled Receptor MRGX2; G Protein-Coupled Receptor MRGX2; Mas-Related G Protein-Coupled Receptor Member X2;

NCIt definition : Mas-related G-protein coupled receptor member X2 (330 aa, 37 kDa) is encoded by the human MRGPRX2 gene. This protein plays a role in G protein-coupled receptor signaling and mast cell activation.;

NCIt note : Mas-related G-protein coupled receptor member X2 has many ligands including cortistatin-14, proadrenomedullin N-terminal peptides PAMP-12 and, at lower extent, PAMP-20, antibacterial protein LL-37, PMX-53 peptide, beta-defensins, and complanadine A. It also binds to small molecules that contain a cyclized tetrahydroisoquinoline (THIQ), such as non-steroidal neuromuscular blocking drugs (NMBDs) and may be associated with drug-related hypersensitivity reactions. (UniProt);

Details

Origin ID

C124965;

UMLS CUI

C1433192;

OMIM relation
- Mas-related g protein-coupled receptor family, member x2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- MRGPRX2 protein, human [MeSH Supplementary Concept]
- MRGPRX2 protein, human [MeSH concept]
gene_encodes_gene_product
- G Protein-Coupled Receptor Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- MRGPRX2 Gene [NCIt concept]
- Receptor Gene [NCIt concept]
gene_product_expressed_in_tissue
- Dorsal Root Ganglion [NCIt concept]
- Mast Cell [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
- Guanine Nucleotide Exchange Factor [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- G Protein-Coupled Receptor Signaling [NCIt concept]
- Ligand Binding [NCIt concept]
- Myeloid Cell Activation Process [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients