BRCA1-A Complex Subunit RAP80

Preferred Label : BRCA1-A Complex Subunit RAP80;

NCIt synonyms : Retinoid X Receptor Interacting Protein; Retinoid X Receptor-Interacting Protein 110; Receptor-Associated Protein 80; Ubiquitin Interaction Motif-Containing Protein 1; Receptor Associated Protein 80; UIMC1;

NCIt definition : BRCA1-A complex subunit RAP80 (719 aa, 80 kDa) is encoded by the human UIMC1 gene. This protein is involved in the recognition of damaged DNA.;

NCIt note : BRCA1-A complex subunit RAP80 specifically binds to histones H2A and H2AX at DNA lesion sites when lysine 63 is ubiquitinated. (UniProt);

Details

Origin ID

C124100;

UMLS CUI

C4085432;

Automatic exact mappings (from CISMeF team)
- Ubiquitin interaction motif-containing protein 1 [OMIM gene]
- ubiquitin interaction motif containing 1 [HGNC gene]
OMIM relation
- Ubiquitin interaction motif-containing protein 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- DNA Repair Gene [NCIt concept]
- UIMC1 Gene [NCIt concept]
gene_product_has_associated_anatomy
- Nucleus [NCIt concept]
gene_product_has_biochemical_function
- Chromatin Remodeling Factor [NCIt concept]
gene_product_has_chemical_classification
- Protein Complex Subunit [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Cycle Checkpoint [NCIt concept]
- DNA Repair [NCIt concept]
- Double Strand Break Repair [NCIt concept]
- Protein-Protein Interaction [NCIt concept]

Keyword's position in hierarchy(ies) :

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