Metalloproteinase Inhibitor 4

Preferred Label : Metalloproteinase Inhibitor 4;

NCIt synonyms : Tissue Inhibitor of Metalloproteinase 4; TIMP-4; Tissue Inhibitor of Metalloproteinases 4;

NCIt definition : Metalloproteinase inhibitor 4 (224 aa, 26 kDa) is encoded by the human TIMP4 gene. This protein plays a role in the inhibition of matrix metalloproteinases.;

NCIt note : Metalloproteinase inhibitor 4 has been shown to inhibit MMP-1, MMP-2, MMP-3, MMP-7 and MMP-9. (UniProt);

Details

Origin ID

C124088;

UMLS CUI

C1744090;

Automatic exact mappings (from CISMeF team)
- Tissue Inhibitor of Metalloproteinase-4 [MeSH Descriptor]
- Tissue inhibitor of metalloproteinase 4 [OMIM gene]
- tissue inhibitor of metalloproteinase-4 [MeSH concept]
OMIM relation
- Tissue inhibitor of metalloproteinase 4 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- TIMP4 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- Enzyme Inhibitor Gene [NCIt concept]
- Proteinase Inhibitor Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- TIMP4 Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_has_organism_source
- Human [NCIt concept]
gene_product_is_element_in_pathway
- Inhibition of Matrix Metalloproteinases Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Enzyme Inhibition [NCIt concept]
- Protein Degradation Inhibition [NCIt concept]
- Regulation of Proteolysis [NCIt concept]

Keyword's position in hierarchy(ies) :

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