Inotersen - CISMeF

Preferred Label : Inotersen;

NCIt synonyms : TTR ASO ISIS-TTR Rx; IONIS TTRRx;

NCIt definition : An antisense oligonucleotide (ASO) targeting transthyretin (TTR), which has potential use in the treatment of TTR amyloidosis (ATTR). Upon subcutaneous administration, inotersen targets and binds to messenger RNA (mRNA) for both variant and wild-type forms of TTR inside liver cells, thereby inhibiting translation of both mutant and wild-type TTR. Inhibition of TTR protein synthesis lowers TTR blood levels and decreases the amount of and/or prevents TTR amyloid deposits, which accumulate in and cause damage to various body organs and tissues. ATTR is caused by mutations in the TTR gene, which lead to TTR protein misfolding; misfolded wild-type and mutant forms of TTR protein accumulate in tissues as amyloid deposits in most ATTR patients.;

UNII : 0IEO0F56LV;

CAS number : 1492984-65-2;

Molecule name : ISIS-TTR Rx; ISIS-TTRRx; ISIS 420915;

Details

Origin ID

C121667;

UMLS CUI

C4731850;

Currated CISMeF NLP mapping
- Inotersen [ICD-11 Extension code]
- Inotersen [MeSH concept]
- Inotersen [MeSH Supplementary Concept]
- Inotersen [SMS substance]
- Inotersen (substance) [SNOMED CT concept]
See also inter- (CISMeF)
- Product containing inotersen (medicinal product) [SNOMED CT concept]
Semantic type(s)
- Nucleic Acid, Nucleoside, or Nucleotide [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Inotersen [MeSH Supplementary Concept]
- Inotersen (substance) [SNOMED CT concept]
- Product containing inotersen (medicinal product) [SNOMED CT concept]
- inotersen [ATC Code]
Validated automatic mappings to BTNT
- inotersen [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
has_target
- Transthyretin [NCIt concept]

Keyword's position in hierarchy(ies) :

Main resources

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