Phosphatidylinositol 4,5-bisphosphate

Preferred Label : Phosphatidylinositol 4,5-bisphosphate;

NCIt synonyms : PIP2; Phosphatidyl-myo-Inositol 4,5-Bisphosphate; 1-Phosphatidyl-D-myo-Inositol 4,5-Bisphosphate; PIPP; Phosphatidylinositol 4 5-bisphosphate; Phosphatidylinositol 4,5-Diphosphate; PtsIns-4,5-P2; PtdIns(4,5)P2; 1-O-(3-sn-Phosphatidyl)-1D-myo-Inositol 4,5-Bis(Dihydrogen Phosphate); 1,2-Diacyl-sn-Glycero-3-Phospho-(1'-myo-Inositol-4',5'-Bisphosphate); 1-Phosphatidyl-1D-myo-Inositol 4,5-Bisphosphate;

NCIt definition : A phospholipid that is a component of the plasma membrane with signal transduction inducing activity. Phosphatidylinositol 4,5-bisphosphate (PIP2) is an intermediate that can be converted into either the second messenger signaling molecules, inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG), or phosphatidylinositol (3,4,5)-trisphosphate (PtdIns(3,4,5)P3; PIP3). Both PIP2 and PIP3 can act as docking phospholipids, which recruit signaling proteins to the plasma membrane and promotes the activation of several signaling cascades.;

ChEBI ID : CHEBI:18348;

Details

Origin ID

C1192;

UMLS CUI

C0070798;

Automatic exact mappings (from CISMeF team)
- Phosphatidylinositol 4,5-bisphosphate 5-phosphatase, a [OMIM gene]
- Smoking Pipes [MeSH Descriptor]
- phosphatidylinositol 4,5-Diphosphate [MeSH concept]
- phosphatidylinositol 4,5-diphosphate [MeSH Descriptor]
Semantic type(s)
- Biologically Active Substance [UMLS semantic type]
- Organic Chemical [UMLS semantic type]
UMLS correspondences (same concept)
- phosphatidylinositol 4,5-Diphosphate [MeSH concept]
- phosphatidylinositol 4,5-diphosphate [MeSH Descriptor]

Keyword's position in hierarchy(ies) :

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