Carbonyl Reductase [NADPH] 1

Preferred Label : Carbonyl Reductase [NADPH] 1;

NCIt synonyms : Prostaglandin-E(2) 9-Reductase; 15-Hydroxyprostaglandin Dehydrogenase; Carbonyl Reductase 1; NADPH-Dependent Carbonyl Reductase 1; Carbonyl Reductase (NADPH) 1; Prostaglandin 9-Ketoreductase; Carbonyl Reductase; 15-Hydroxyprostaglandin Dehydrogenase [NADP( )]; CBR1;

NCIt definition : Carbonyl reductase [NADPH] 1 (277 aa, 30 kDa) is encoded by the human CBR1 gene. This protein plays a role in the reduction of carbonyl compounds.;

NCIt note : Carbonyl reductase [NADPH] 1 substrates include quinones, prostaglandins, and menadione. Additionally, this enzyme catalyzes the reduction of the antitumor anthracyclines doxorubicin and daunorubicin to the cardiotoxic compounds doxorubicinol and daunorubicinol. (UniProt);

Details

Origin ID

C118565;

UMLS CUI

C2604870;

Automatic exact mappings (from CISMeF team)
- 15-hydroxyprostaglandin dehydrogenase [MeSH concept]
- 15-hydroxyprostaglandin dehydrogenase [MeSH Supplementary Concept]
- 15-hydroxyprostaglandin dehydrogenase [ORDO Gene]
- 15-hydroxyprostaglandin dehydrogenase [OMIM gene]
- 15-hydroxyprostaglandin dehydrogenase [HGNC gene]
- 15-hydroxyprostaglandin dehydrogenase (nadp+) [SNOMED Notion]
- 15-hydroxyprostaglandin dehydrogenase (nicotinamide adenine dinucleotide phosphate ^+^) (substance) [SNOMED CT concept]
- 15-hydroxyprostaglandin-D dehydrogenase (NADP+) activity [GO term]
- Carbonyl Reductase (NADPH) [MeSH Descriptor]
- Carbonyl reductase (reduced nicotinamide adenine dinucleotide phosphate) (substance) [SNOMED CT concept]
- Carbonyl reductase 1 [OMIM gene]
- alcohol oxidoreductases [MeSH Descriptor]
- carbonyl reductase 1 [HGNC gene]
- prostaglandin-E2 9-reductase [MeSH Supplementary Concept]
OMIM relation
- Carbonyl reductase 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- CBR1 protein, human [MeSH Supplementary Concept]
- CBR1 protein, human [MeSH concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- CBR1 Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Oxidoreductase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Exosome [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Arachidonic Acid Metabolism Pathway [NCIt concept]
- Metabolism of Xenobiotics by Cytochrome P450 Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Drug Metabolism Induction [NCIt concept]
- Eicosanoid Modulation [NCIt concept]
- Oxidation [NCIt concept]
- Oxidation/Reduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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