Secretory Phospholipase A2 Receptor

Preferred Label : Secretory Phospholipase A2 Receptor;

NCIt synonyms : PLA2-R; Phospholipase A2 Receptor 1; 180 kDa Secretory Phospholipase A2 Receptor; M-Type Receptor; C-Type Lectin Domain Family 13 Member C;

NCIt related terms : PHOSPHOLIPASE A2 RECEPTOR; M-Type Phospholipase A2 Receptor; PLA2R;

NCIt definition : Secretory phospholipase A2 receptor (1463 aa, 169 kDa) is encoded by the human PLA2R1 gene. This protein plays a role in the modulation of phospholipase activity.;

Alternative definition : CDISC: An antigen encoded by the PLA2R1 gene and is involved in the modulation of phospholipase activity. It can be considered as an autoantigen and is commonly associated with autoimmune disease membranous nephropathy.;

NCIt note : Secretory phospholipase A2 receptor is either cleaved by metalloproteinases or the gene underogoes alternative splicing to form soluble secretory phospholipase A2 receptor (Soluble PLA2-R or Soluble PLA2R), which is comprised of the entire extracellular domain of the receptor. The soluble form acts as a negative regulator of the membrane bound form. (UniProt);

Details

Origin ID

C114547;

UMLS CUI

C1670125;

Automatic exact mappings (from CISMeF team)
- Phospholipase a2 receptor 1 [OMIM gene]
- phospholipase A2 receptor 1 [HGNC gene]
- phospholipases A2, secretory [MeSH Descriptor]
- phospholipases a2 [MeSH Descriptor]
OMIM relation
- Phospholipase a2 receptor 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- PLA2R1 protein, human [MeSH Supplementary Concept]
- PLA2R1 protein, human [MeSH concept]
concept_is_in_subset
- CDISC SDTM Binding Agent for Immunogenicity Tests Terminology [NCIt concept]
- CDISC SDTM Terminology [NCIt concept]
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- Clinical Data Interchange Standards Consortium Terminology [NCIt concept]
gene_encodes_gene_product
- Ligand Binding Protein Gene [NCIt concept]
- PLA2R1 Gene [NCIt concept]
- Receptor Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
gene_product_is_element_in_pathway
- Phagocytosis Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Induction of Cell Senescence [NCIt concept]
- Ligand Binding [NCIt concept]
- Phospholipid Metabolism [NCIt concept]
- Receptor Mediated Endocytosis [NCIt concept]
- Receptor Signaling [NCIt concept]

Keyword's position in hierarchy(ies) :

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