CDGSH Iron-Sulfur Domain-Containing Protein 1

Preferred Label : CDGSH Iron-Sulfur Domain-Containing Protein 1;

NCIt synonyms : Zinc Finger CDGSH-Type Domain 1; CDGSH Iron Sulfur Domain-Containing Protein 1; MitoNEET; Mitochondrial Asn-Glu-Glu-Thr (NEET); CISD1;

NCIt definition : CDGSH iron-sulfur domain-containing protein 1 (108 aa, 12 kDa) is encoded by the human CISD1 gene. This protein is involved in both iron-sulfur cluster binding and the regulation of cell respiration.;

NCIt note : CDGSH iron-sulfur domain-containing protein 1 binds the anti-diabetes drug, pioglitazone. This interaction stabilizes the iron-sulfur (2Fe-2s) cluster. (UniProt);

Details

Origin ID

C113135;

UMLS CUI

C2003363;

Automatic exact mappings (from CISMeF team)
- Cdgsh iron sulfur domain protein 1 [OMIM gene]
OMIM relation
- Cdgsh iron sulfur domain protein 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- CISD1 protein, human [MeSH Supplementary Concept]
- CISD1 protein, human [MeSH concept]
gene_encodes_gene_product
- CISD1 Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
gene_product_has_associated_anatomy
- Outer Mitochondrial Membrane [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Cell Respiration [NCIt concept]
- Ligand Binding [NCIt concept]
- Metal Ion Binding [NCIt concept]

Keyword's position in hierarchy(ies) :

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