Islet Amyloid Polypeptide

Preferred Label : Islet Amyloid Polypeptide;

NCIt synonyms : DAP; Insulinoma Amyloid Peptide; Diabetes-Associated Peptide; Amylin;

NCIt definition : Islet amyloid polypeptide (89 aa, 10 kDa) is encoded by the human IAPP gene. This protein plays a role in the regulation of glucose metabolism.;

NCIt note : The mature islet amyloid polypeptide protein is largely unstructured in the absence of a cognate ligand, and has a strong tendency to form fibrillar aggregates. Homodimerization may be the first step of amyloid formation. (UniProt); Islet amyloid polypeptide is the peptide subunit of amyloid found in pancreatic islets of type 2 diabetic patients and in insulinomas. (UniProt);

Details

Origin ID

C112881;

UMLS CUI

C3813125;

Automatic exact mappings (from CISMeF team)
- Amylin (substance) [SNOMED CT concept]
- Aspartyl aminopeptidase [OMIM gene]
- Death-associated protein [OMIM gene]
- Islet amyloid polypeptide [OMIM gene]
- dose area product [Radlex concept]
- glyceronephosphate O-acyltransferase [ORDO Gene]
- islet amyloid polypeptide [MeSH concept]
- islet amyloid polypeptide [MeSH Descriptor]
- islet amyloid polypeptide [HGNC gene]
OMIM relation
- Islet amyloid polypeptide [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
gene_encodes_gene_product
- IAPP Gene [NCIt concept]
- Peptide Hormone Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
gene_product_is_element_in_pathway
- Maturity Onset Diabetes of the Young Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Apoptosis [NCIt concept]
- Intercellular Communication Process [NCIt concept]
- Receptor Binding [NCIt concept]

Keyword's position in hierarchy(ies) :

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