MSR1 wt Allele

Preferred Label : MSR1 wt Allele;

NCIt synonyms : Macrophage Scavenger Receptor 1 wt Allele; SCARA1; SR-A; CD204; Macrophage Scavenger Receptor Gene; phSR1; phSR2; SRA;

NCIt definition : Human MSR1 wild-type allele is located in the vicinity of 8p22 and is approximately 450 kb in length. This allele, which encodes macrophage scavenger receptor types I and II protein, is involved in the modulation of cholesterol and lipoprotein transport. Mutation of the gene is associated with Barrett esophagus and prostate cancer.;

NCIt note : The MSR1 gene encodes three different isoforms (Types I, II, and III) generated by alternative splicing. Isoform III does not internalize acetylated LDL. (EntrezGene and UniProt);

GenBank Accession Number : D13263;

Details

Origin ID

C112505;

UMLS CUI

C3811244;

Automatic exact mappings (from CISMeF team)
- Macrophage scavenger receptor [OMIM gene]
- SR-AT [MeSH concept]
- SR-AT [MeSH Supplementary Concept]
- SRS-A [MeSH Descriptor]
- SRS-A [MeSH concept]
- Slow reacting substance-A of anaphylaxis (substance) [SNOMED CT concept]
- macrophage scavenger receptor 1 [ORDO Gene]
- renin-angiotensin system [MeSH Descriptor]
- staphylococcus aureus [MeSH Descriptor]
OMIM relation
- Macrophage scavenger receptor [OMIM gene]
Semantic type(s)
- Gene or Genome [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_found_in_organism
- Human [NCIt concept]
gene_in_chromosomal_location
- 8p22 [NCIt concept]
gene_is_element_in_pathway
- Phagocytosis Pathway [NCIt concept]
gene_plays_role_in_process
- Cholesterol Homeostasis [NCIt concept]
- Ligand Binding [NCIt concept]
- Lipid Transport [NCIt concept]
- Receptor Signaling [NCIt concept]

Keyword's position in hierarchy(ies) :

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