Etanidazole - CISMeF

Preferred Label : Etanidazole;

NCIt synonyms : 1H-Imidazole-1-acetamide, N-(2-hydroxyethyl)-2-nitro-; 2-Nitroimidazole-1-acetamide, N-(2-hydroxyethyl)-;

NCIt definition : A 2-nitroimidazole with radiosensitizing properties. Etanidazole depletes glutathione and inhibits glutathione transferase, thereby enhancing the cytotoxicity of ionizing radiation. This agent may also be useful as an imaging agent for identifying hypoxic, drug-resistant regions of primary tumors or metastases. (NCI04);

Alternative definition : NCI-GLOSS: A drug that increases the effectiveness of radiation therapy.;

UNII : 30DKA3Q1HL;

InChIKey : WCDWBPCFGJXFJZ-UHFFFAOYSA-N;

CAS number : 22668-01-5;

Molecule name : SR-2508;

Chemical formula : C7H10N4O4;

NSC code : 301467;

Codes from synonyms : NSC0301467; CDR0000045213;

Details

Origin ID

C1092;

UMLS CUI

C0059682;

Currated CISMeF NLP mapping
- etanidazole [MeSH Descriptor]
- etanidazole [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- etanidazole [MeSH concept]
- etanidazole [MeSH Descriptor]
chemical_or_drug_affects_gene_product
- Glutathione S-Transferase [NCIt concept]
chemical_or_drug_has_mechanism_of_action
- Enzyme Inhibition [NCIt concept]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Glutathione S-Transferase [NCIt concept]
is_component_of_chemotherapy_regimen
- Carboplatin/Cyclophosphamide/Etanidazole [NCIt concept]
- Carboplatin/Etoposide/Ifosfamide/Etanidazole [NCIt concept]
- Cyclophosphamide/Etanidazole [NCIt concept]
- Etanidazole/Cisplatin Regimen [NCIt concept]
- Etanidazole/Melphalan/Prednisone [NCIt concept]

Keyword's position in hierarchy(ies) :

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