Preferred Label : Monosialotetrahexosylganglioside;
NCIt synonyms : Ganglioside GM-1; Monosialoanglioside GM1; GM-1; GM1;
NCIt related terms : GANGLIOSIDE GM1;
NCIt definition : A glycosphingolipid containing a sialic acid residue found in neuronal cell membranes,
with potential neuroprotective and neuroregenerative activities. Upon administration,
monosialotetrahexosylganglioside, also called GM-1, is able to both prevent neurologic
damage and induce regeneration of damaged neurons through neurotrophic repair mechanisms,
enhancement of the production of neutrophins, and augmenting neurite outgrowth. In
addition, GM-1 exerts anti-excitotoxic activity, prevents necrosis, and improves neuronal
recovery and function.;
Alternative definition : CDISC: A sialic acid-containing glycosphingolipid antigen and a component of the cell
plasma membrane that modulates cell signal transduction, with a designation of GM1.
It can be considered as an autoantigen and is commonly associated with autoimmune
neuropathies such as Guillain-Barre syndrome and multiple sclerosis.;
Origin ID : C107389;
UMLS CUI : C0016895;
Currated CISMeF NLP mapping
- Semantic type(s)
- UMLS correspondences (same concept)
- concept_is_in_subset
