" /> Agerafenib - CISMeF





Preferred Label : Agerafenib;

NCIt synonyms : 1-(3-(6,7-Dimethoxyquinazolin-4-yloxy)phenyl)-3-(5-(1,1,1-trifluoro-2-methylpropan-2-yl)isoxazol-3-yl)urea Hydrochloride;

NCIt definition : An orally available v-raf murine sarcoma viral oncogene homolog B1 (B-raf) serine/threonine protein kinase inhibitor with potential antineoplastic activity. Agerafenib specifically and selectively inhibits the activity of the mutated form (V600E) of B-raf kinase. This inhibits the activation of the RAF/mitogen-activated protein kinase kinase (MEK)/extracellular signal-related kinase (ERK) signaling pathway and may result in a decrease in the proliferation of tumor cells expressing the mutated B-raf gene. The Raf mutation BRAF V600E, in which valine is substituted for glutamic acid at residue 600, is frequently found in a variety of human tumors and results in the constitutive activation of the RAF/MEK/ERK signaling pathway that regulates cellular proliferation and survival.;

UNII : 78I4VEX88N;

InChIKey : DKNUPRMJNUQNHR-UHFFFAOYSA-N;

CAS number : 1188910-76-0; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1188910-76-0 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Molecule name : AC013773; CEP-32496; RXDX-105;

NCI Metathesaurus CUI : CL550786;

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12/05/2024


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