Bactericidal Permeability-Increasing Protein

Preferred Label : Bactericidal Permeability-Increasing Protein;

NCIt synonyms : BPI Fold Containing Family D, Member 1; BPI;

NCIt related terms : Bactericidal/Permeability-Increasing Protein; RBPI;

NCIt definition : Bactericidal permeability-increasing protein (487 aa, 54 kDa) is encoded by the human BPI gene. This protein is involved in both defense against gram-negative bacterial infections and lipopolysaccharide binding.;

Alternative definition : CDISC: An antigen encoded by the BPI gene and an endogenous antibiotic, cytotoxic protein in the innate immune system. It can be considered as an autoantigen and is commonly associated with the autoimmune diseases inflammatory bowel disease, systemic lupus erythematosus and rheumatoid arthritis.;

Details

Origin ID

C106602;

UMLS CUI

C1453589;

Automatic exact mappings (from CISMeF team)
- Bactericidal permeability-increasing protein [OMIM gene]
- bactericidal permeability increasing protein [MeSH concept]
- bactericidal permeability increasing protein [MeSH Supplementary Concept]
OMIM relation
- Bactericidal permeability-increasing protein [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- BPI protein, human [MeSH concept]
concept_is_in_subset
- CDISC SDTM Binding Agent for Immunogenicity Tests Terminology [NCIt concept]
- CDISC SDTM Terminology [NCIt concept]
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- Clinical Data Interchange Standards Consortium Terminology [NCIt concept]
gene_encodes_gene_product
- BPI Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Ligand Binding [NCIt concept]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients