Orexin - CISMeF

Preferred Label : Orexin;

NCIt synonyms : Hypocretin; Hcrt; Prepro-Orexin; Preproorexin;

NCIt definition : Orexin (131 aa, 13 kDa) is encoded by the human HCRT gene. This protein is involved in neuropeptide-dependent signaling and feeding behavior.;

NCIt note : Orexin is proteolytically processed to form 2 active neuropeptides orexin-A (hypocretin-1, Hcrt1) and orexin-B (hypocretin-2, Hcrt2). (UniProt);

Details

Origin ID

C106421;

UMLS CUI

C1527908;

Automatic exact mappings (from CISMeF team)
- Hypocretin [OMIM gene]
- Orexin (substance) [SNOMED CT concept]
- Orexin-A [MeSH concept]
- Orexins [MeSH Descriptor]
- Orexins [MeSH concept]
- hypocretin neuropeptide precursor [ORDO Gene]
- hypocretin neuropeptide precursor [HGNC gene]
OMIM relation
- Hypocretin [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
UMLS correspondences (same concept)
- HCRT protein, human [MeSH Supplementary Concept]
- HCRT protein, human [MeSH concept]
gene_encodes_gene_product
- HCRT Gene [NCIt concept]
gene_product_has_associated_anatomy
- Extracellular Space [NCIt concept]
- Secretory Granule [NCIt concept]
gene_product_is_element_in_pathway
- Neuroactive Ligand-Receptor Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Appetite [NCIt concept]
- G Protein-Coupled Receptor Signaling [NCIt concept]
- Neuronal Transmission [NCIt concept]

Keyword's position in hierarchy(ies) :

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