Cytochrome P450 2A6

Preferred Label : Cytochrome P450 2A6;

NCIt synonyms : EC 1.14.13.-; CYP2A6; CYPIIA6; Cytochrome P450(I); 1,4-Cineole 2-Exo-Monooxygenase; Coumarin 7-Hydroxylase; Cytochrome P450 IIA3;

NCIt definition : Cytochrome P450 2A6 (494 aa, 57 kDa) is encoded by the human CYP2A6 gene. This protein is involved in the metabolism of xenobiotics.;

NCIt note : Substrates for cytochrome P450 2A6 include coumarin, aflatoxin B1, eucalyptol, phenacetin, nicotine, cyclophosphamide and ifosphamide. (UniProt);

Details

Origin ID

C105905;

UMLS CUI

C3884187;

Currated CISMeF NLP mapping
- Cytochrome P-450 CYP2A6 [MeSH Descriptor]
- Cytochrome P-450 CYP2A6 [MeSH concept]
- Cytochrome p450 CYP2A6 enzyme (substance) [SNOMED CT concept]
- Cytochrome p450, subfamily iia, polypeptide 6 [OMIM Phenotype]
OMIM relation
- Cytochrome p450, subfamily iia, polypeptide 6 [OMIM Phenotype]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
UMLS correspondences (same concept)
- CYP2A6 protein, human [MeSH concept]
- CYP2A6 protein, human [MeSH Supplementary Concept]
- Cytochrome P-450 CYP2A6 [MeSH Descriptor]
- Cytochrome P-450 CYP2A6 [MeSH concept]
- Cytochrome p450 CYP2A6 enzyme (substance) [SNOMED CT concept]
Validated automatic mappings to BTNT
- CYP2A6 protein, human [MeSH concept]
- CYP2A6 protein, human [MeSH Supplementary Concept]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- CYP2A6 Gene [NCIt concept]
- Cytochrome P450 Family Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Oxidoreductase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Endoplasmic Reticulum [NCIt concept]
gene_product_has_chemical_classification
- Heme Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- Caffeine Metabolism Pathway [NCIt concept]
- Drug Metabolism by Cytochrome P450 Pathway [NCIt concept]
- Drug Metabolism by Non-CYP450 Enzymes Pathway [NCIt concept]
- Metabolism of Xenobiotics by Cytochrome P450 Pathway [NCIt concept]
- Retinol Metabolism Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Detoxification [NCIt concept]
- Hydroxylation [NCIt concept]
- Intermediary Metabolic Process [NCIt concept]
- Oxidation [NCIt concept]
- Oxidation/Reduction [NCIt concept]
- Xenobiotic Metabolism [NCIt concept]

Keyword's position in hierarchy(ies) :

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