Hairy/Enhancer-Of-Split Related With YRPW Motif Protein 2

Preferred Label : Hairy/Enhancer-Of-Split Related With YRPW Motif Protein 2;

NCIt synonyms : hCHF1; HRT-2; HES-Related Repressor Protein 2; Hairy and Enhancer of Split-Related Protein 2; Cardiovascular Helix-Loop-Helix Factor 1; Hairy-Related Transcription Factor 2; Protein Gridlock Homolog; Class B Basic Helix-Loop-Helix Protein 32; HEY2; bHLHb32; hHRT2;

NCIt definition : Hairy/enhancer-of-split related with YRPW motif protein 2 (337 aa, 36 kDa) is encoded by the human HEY2 gene. This protein is involved in both the negative regulation of gene expression and Notch-dependent signaling.;

NCIt note : Hairy/enhancer-of-split related with YRPW motif protein 2 binds to the canonical E box sequence 5'-CACGTG-3'. (UniProt);

Details

Origin ID

C104540;

UMLS CUI

C3538964;

OMIM relation
- Hes-related family bhlh transcription factor with yrpw motif 2 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]
concept_is_in_subset
- CTRP Biomarker Terminology [NCIt concept]
- CTRP Molecular Genetic Biomarker Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
gene_encodes_gene_product
- HEY2 Gene [NCIt concept]
- Regulatory Gene [NCIt concept]
- Transcription Regulation Gene [NCIt concept]
gene_product_has_biochemical_function
- Transcription Repressor/Corepressor [NCIt concept]
gene_product_has_structural_domain_or_motif
- bHLH Domain [NCIt concept]
gene_product_is_element_in_pathway
- Segmentation Clock Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Pattern Formation [NCIt concept]
- Protein-Protein Interaction [NCIt concept]
- Signal Transduction [NCIt concept]
- Transcriptional Regulation [NCIt concept]
- Transcriptional Repression [NCIt concept]

Keyword's position in hierarchy(ies) :

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