" /> Cefepime Hydrochloride - CISMeF





Preferred Label : Cefepime Hydrochloride;

NCIt synonyms : Pyrrolidinium, 1-((7-(((2-amino-4-thiazolyl)(methoxyimino)acetyl)amino)-2-carboxy-8-oxo-5-thia-1-azabicyclo(4.2.0)oct-2-en-3-yl)methyl)-1-methyl-, hydroxide, inner salt, (6R-(6alpha,7beta(Z)))-; Cefepime;

NCIt definition : The hydrochloride salt of a semi-synthetic, beta-lactamase-resistant, fourth-generation cephalosporin antibiotic derived from an Acremonium fungal species with broad-spectrum bactericidal activity. Administered parenterally, cefepime inhibits bacterial cell wall synthesis by binding to and inactivating penicillin-binding proteins (PBP) located on the inner membrane of the bacterial cell wall. Inactivation of PBPs interferes with the cross-linkage of peptidoglycan chains necessary for bacterial cell wall strength and rigidity, resulting in a reduction of bacterial cell wall stability and cell lysis. This agent is more active against a variety of Gram-positive pathogens compared to third-generation cephalosporins.;

UNII : I8X1O0607P;

InChIKey : LRAJHPGSGBRUJN-OMIVUECESA-N;

CAS number : 123171-59-5;

Drug name : Maxipime;

Chemical formula : C19H24N6O5S2.2ClH.H2O;

ChEBI ID : CHEBI:31368;

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06/05/2025


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