Threonine Aspartase 1

Preferred Label : Threonine Aspartase 1;

NCIt synonyms : Taspase 1; EC 3.4.25.-; Taspase-1; TASP1;

NCIt definition : Threonine aspartase 1 (420 aa, 44 kDa) is encoded by the human TASP1 gene. This protein plays a role in the proteolysis of histone-lysine N-methyltransferase MLL protein.;

NCIt note : Threonine aspartase 1 cleaves histone-lysine N-methyltransferase MLL which both increases the stability and enhances the nuclear localization for the MLL protein. (OMIM); Threonine aspartase 1 undergoes posttranslational autoproteolytic processing to generate alpha and beta subunits, which reassemble non-covalently into the active alpha2-beta2 heterotetramer. (EntrezGene and UniProt);

Details

Origin ID

C102896;

UMLS CUI

C3541322;

OMIM relation
- Threonine aspartase 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
gene_encodes_gene_product
- Enzyme Gene [NCIt concept]
- Hydrolase Gene [NCIt concept]
- Peptidase Gene [NCIt concept]
- TASP1 Gene [NCIt concept]
gene_product_has_biochemical_function
- Endopeptidase [NCIt concept]
gene_product_has_structural_domain_or_motif
- Protease Domain [NCIt concept]
- Substrate Interaction Domain [NCIt concept]
gene_product_plays_role_in_biological_process
- Hydrolysis [NCIt concept]
- Protein Cleavage [NCIt concept]
- Transcriptional Activation [NCIt concept]

Keyword's position in hierarchy(ies) :

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