Sacituzumab Govitecan

Preferred Label : Sacituzumab Govitecan;

NCIt synonyms : hRS7-SN38 Antibody Drug Conjugate; RS7-SN38; Sacituzumab Govitecan-hziy;

NCIt definition : An antibody drug conjugate containing the humanized monoclonal antibody, hRS7, against tumor-associated calcium signal transducer 2 (TACSTD2 or TROP2) and linked to the active metabolite of irinotecan, 7-ethyl-10-hydroxycamptothecin (SN-38), with potential antineoplastic activity. The antibody moiety of sacituzumab govitecan selectively binds to TROP2. After internalization and proteolytic cleavage, SN-38 selectively stabilizes topoisomerase I-DNA covalent complexes, resulting in DNA breaks that inhibit DNA replication and trigger apoptosis. TROP2, also known as epithelial glycoprotein-1 (EGP-1), is a transmembrane calcium signal transducer that is overexpressed by a variety of human epithelial carcinomas; this antigen is involved in the regulation of cell-cell adhesion and its expression is associated with increased cancer growth, aggressiveness and metastasis.;

UNII : M9BYU8XDQ6;

CAS number : 1491917-83-9; a href https://gsrs.ncats.nih.gov/ginas/app/beta/browse-substance?search 1491917-83-9 alt lien vers site G-SRS target _blank img src /img/logos/logo_g-srs.png alt Logo G-SRS /a ;

Drug name : Trodelvy;

Molecule name : IMMU-132;

Codes from synonyms : 456;

Details

Origin ID

C102783;

UMLS CUI

C4086837;

Automatic exact mappings (from CISMeF team)
- sacituzumab govitecan [ATC Code]
CISMeF manual mappings
- Sacituzumab govitecan (substance) [SNOMED CT concept]
Currated CISMeF NLP mapping
- sacituzumab govitecan [MeSH Supplementary Concept]
- sacituzumab govitecan [MeSH concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Product containing sacituzumab govitecan (medicinal product) [SNOMED CT concept]
- Sacituzumab govitecan (substance) [SNOMED CT concept]
- sacituzumab govitecan [MeSH Supplementary Concept]
- sacituzumab govitecan [ATC Code]
concept_is_in_subset
- CTRP Agent Terminology [NCIt concept]
- CTRP Terminology [NCIt concept]
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- GDC Terminology [NCIt concept]
- GDC Therapeutic Agent Terminology [NCIt concept]
- GDC Value Terminology [NCIt concept]
- HemOnc Agent Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]
- NCIt Antineoplastic Agent Terminology [NCIt concept]
has_target
- Tumor-Associated Calcium Signal Transducer 2 [NCIt concept]
is_component_of_chemotherapy_regimen
- Sacituzumab Govitecan Regimen [NCIt concept]

Keyword's position in hierarchy(ies) :

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