Preferred Label : Adenovirus Encoding Tyrosinase/MART-1/MAGEA6-transduced Autologous Dendritic Cell
Vaccine;
NCIt synonyms : AdVTMM2-transduced Dendritic Cell Vaccine;
NCIt definition : A cell-based cancer vaccine composed of autologous dendritic cells (DCs) transduced
with a recombinant adenoviral vector encoding three full length human melanoma associated
antigens (MAAs), tyrosinase, melan-A (MART-1) and the melanoma antigen A6 (MAGEA6),
with potential antineoplastic activity. Upon intradermal administration, adenovirus
encoding tyrosinase/MART-1/MAGEA6-transduced autologous DC vaccine may stimulate a
cytotoxic T lymphocyte (CTL) response against tyrosinase/MART-1/MAGEA6-positive tumor
cells, which may result in tumor cell death and decreased tumor growth. Tyrosinase,
a melanoma-specific differentiation antigen, catalyzes the first step of melanin synthesis
in melanocytes. Vaccination with multi-antigen modified DC may improve the efficacy
of the DC immunotherapy.;
NCI Metathesaurus CUI : CL437010;
Origin ID : C102753;
UMLS CUI : C3640934;
Semantic type(s)
- Cell [UMLS semantic type]
- concept_is_in_subset
- has_target
