Proteinase-Activated Receptor 4

Preferred Label : Proteinase-Activated Receptor 4;

NCIt synonyms : Proteinase-Activated Receptor-4; Thrombin Receptor-Like 3; Coagulation Factor II Receptor-Like 3; PAR-4; Protease-Activated Receptor-4;

NCIt definition : Proteinase-activated receptor 4 (385 aa, 41 kDa) is encoded by the human F2RL3 gene. This protein plays a role in both the mediation of receptor signaling and the promotion of platelet activation.;

NCIt note : Proteinase-activated receptor 4 is cleaved by either trypsin or thrombin. Proteolytic cleavage of the receptor generates a new N-terminus that functions as a tethered ligand. (UniProt);

Details

Origin ID

C102544;

UMLS CUI

C1449190;

OMIM relation
- Coagulation factor II receptor-like 3 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Receptor [UMLS semantic type]
UMLS correspondences (same concept)
- F2RL3 protein, human [MeSH concept]
gene_encodes_gene_product
- F2RL3 Gene [NCIt concept]
- G Protein-Coupled Receptor Gene [NCIt concept]
- Ligand Binding Protein Gene [NCIt concept]
- Receptor Gene [NCIt concept]
gene_product_has_associated_anatomy
- Plasma Membrane [NCIt concept]
gene_product_has_biochemical_function
- Cell Surface Receptor [NCIt concept]
- Guanine Nucleotide Exchange Factor [NCIt concept]
gene_product_has_chemical_classification
- Transmembrane Protein [NCIt concept]
gene_product_has_structural_domain_or_motif
- Ligand Binding Domain [NCIt concept]
- Transmembrane Domain [NCIt concept]
gene_product_is_element_in_pathway
- Aspirin Inhibition of Platelet Activation Pathway [NCIt concept]
- Neuroactive Ligand-Receptor Signaling Pathway [NCIt concept]
- Thrombin/Protease-Activated Receptor Signaling Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- G Protein-Coupled Receptor Signaling [NCIt concept]
- Ligand Binding [NCIt concept]
- Platelet Activation [NCIt concept]
- Receptor Signaling [NCIt concept]
- Signal Transduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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