Egl Nine Homolog 1

Preferred Label : Egl Nine Homolog 1;

NCIt synonyms : Hypoxia-Inducible Factor Prolyl Hydroxylase 2; HIF-PH2; Prolyl Hydroxylase Domain-Containing Protein 2; SM-20; HPH-2; EC 1.14.11.29; PHD2; HIF-Prolyl Hydroxylase 2; EGLN1;

NCIt definition : Egl nine homolog 1 (426 aa, 46 kDa) is encoded by the human EGLN1 gene. This protein plays a role in the modification of hypoxia-inducible factor alpha proteins in response to hypoxic conditions.;

NCIt note : The activity of egl nine homolog 1 is inhibited in ischemic tissues. (Nature. 2011; 479:122-126.);

Details

Origin ID

C101545;

UMLS CUI

C3540623;

Automatic exact mappings (from CISMeF team)
- Egl9 family hypoxia-inducible factor 1 [OMIM gene]
- Hypoxia-Inducible Factor-Proline dioxygenases [MeSH Descriptor]
- Hypoxia-Inducible factor prolyl hydroxylase 2 [MeSH concept]
- Polyhomeotic homolog 2 [OMIM gene]
- egl-9 family hypoxia inducible factor 1 [ORDO Gene]
OMIM relation
- Egl9 family hypoxia-inducible factor 1 [OMIM gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
gene_encodes_gene_product
- EGLN1 Gene [NCIt concept]
- Enzyme Gene [NCIt concept]
- Oxidoreductase Gene [NCIt concept]
gene_product_has_associated_anatomy
- Cytosol [NCIt concept]
- Nucleus [NCIt concept]
gene_product_has_structural_domain_or_motif
- Substrate Interaction Domain [NCIt concept]
gene_product_is_element_in_pathway
- HIF-1-Alpha Transcription Factor Pathway [NCIt concept]
- Renal Cell Carcinoma Pathway [NCIt concept]
gene_product_plays_role_in_biological_process
- Cellular Stress Response [NCIt concept]
- Homeostatic Process [NCIt concept]
- Iron Chelation [NCIt concept]
- Oxidation [NCIt concept]
- Oxidation/Reduction [NCIt concept]

Keyword's position in hierarchy(ies) :

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