ximelagatran - CISMeF

Preferred Label : ximelagatran;

MeSH note : prodrug (via hydroxylation) of melagatran & a direct thrombin inhibitor; liver toxicity concerns so AZD0837 being developed to replace this;

CISMeF synonym : H 376 95; exanta;

MeSH synonym : xi-melagatran; glycine, N-((1)1-cyclohexyl-2-((2)-((((4-(amino(hydroxyimino)methyl)phenyl)methyl)amino)carbonyl)-1-azetidinyl)2-oxoethyl)-ethyl ester; glycine, N-((1R)1-cyclohexyl-2-((2S)-((((4-(amino(hydroxyimino)methyl)phenyl)methyl)amino)carbonyl)-1-azetidinyl)2-oxoethyl)-ethyl ester;

MeSH hyponym : H 376-95;

Is substance : O;

UNII : 49HFB70472;

InChIKey : ZXIBCJHYVWYIKI-PZJWPPBQSA-N;

Details

Origin ID

C426686;

UMLS CUI

C0966370;

ATC code(s)
- ximelagatran [ATC Code]
Currated CISMeF NLP mapping
- Ximelagatran [NCIt concept]
- Ximelagatran (substance) [SNOMED CT concept]
- ximelagatran [ATC Code]
MeSH term(s) associated for indexing
- azetidines [MeSH Descriptor]
- benzylamines [MeSH Descriptor]
Pharmacological action(s)
- antithrombins [MeSH Descriptor]
Record concept(s)
- H 376 95 [MeSH concept]
- exanta [MeSH concept]
- ximelagatran [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Ximelagatran [NCIt concept]
- Ximelagatran (substance) [SNOMED CT concept]
- ximelagatran [ATC Code]

Keyword's position in hierarchy(ies) :

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