tirilazad - CISMeF

Preferred Label : tirilazad;

MeSH note : a lazaroid; potent inhibitor of iron-dependent lipid peroxidation; has shown excellent activity in in vivo models of experimental central nervous system trauma & ischemia; structure given in first source; tradename Freedox;

CISMeF synonym : U 74006F; freedox; pharmacia brand of tirilazad mesylate hydrate; U-74006;

MeSH hyponym : U74006F; U-74006F; 21-(4-(2,6-di-1-pyrrolidinyl-4-pyrimidinyl)-1-piperazinyl)-16-methylpregna-1,4,9(11)-triene-3,20-dione monomethane sulfonate; tirilazad mesylate;

MeSH CAS label : Pregna-1,4,9(11)-triene-3,20-dione, 21-(4-(2,6-di-1-pyrrolidinyl-4-pyrimidinyl)-1-piperazinyl)-16-methyl-, (16alpha)-, monomethanesulfonate;

MeSH Related Number : tirilazad mesylate hydrate; 110101-66-1 (tirilazad); 111793-42-1 (mesylate:hydrate); 110101-67-2; 111793-42-1 (tirilazad mesylate hydrate); HXS259UWKW;

Registry Number MeSH : 110101-67-2;

Related CAS MeSH : 111793-42-1 (tirilazad mesylate hydrate);

related registry number list (CISMeF) : 110101-66-1 (tirilazad); 111793-42-1 (mesylate:hydrate);

Is substance : O;

UNII : YD064E883I;

Details

Origin ID

C053355;

UMLS CUI

C0245179;

ATC code(s)
- tirilazad [ATC Code]
Currated CISMeF NLP mapping
- Tirilazad [NCIt concept]
MeSH term(s) associated for indexing
- pregnatrienes [MeSH Descriptor]
Pharmacological action(s)
- antioxidants [MeSH Descriptor]
- neuroprotective agents [MeSH Descriptor]
Record concept(s)
- U 74006F [MeSH concept]
- U-74006 [MeSH concept]
- freedox [MeSH concept]
- pregna-1,4,9(11)-triene-3,20-dione, 21-(4-(2,6-di-1-pyrrolidinyl-4-pyrimidinyl)-1-piperazinyl)-16-methyl-, (16alpha)-, monomethanesulfonate [MeSH concept]
- tirilazad [MeSH concept]
- tirilazad mesylate hydrate [MeSH concept]
Semantic type(s)
- Organic Chemical [UMLS semantic type]
- Pharmacologic Substance [UMLS semantic type]
UMLS correspondences (same concept)
- Tirilazad [NCIt concept]
- tirilazad [ATC Code]
Validated automatic mappings to BTNT
- Tirilazad Mesylate [NCIt concept]
- tirilazad [ATC Code]

Keyword's position in hierarchy(ies) :

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