trichostatin A

Preferred Label : trichostatin A;

MeSH note : chelates zinc ion in the active site of histone deacetylases, resulting in preventing histone unpacking so DNA is less available for transcription; do not confuse with TRICHOSANTHIN which is a protein; found in STREPTOMYCES;

CISMeF synonym : A 300; tricostatin A; trychostatin A;

MeSH synonym : TSA antibioitc; 2,4-Heptadienamide, 7-(4-(dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo-; 7-(4-(Dimethylamino)phenyl)-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide;

MeSH CAS label : 7-(4-(dimethylamino)phenyl)-N-hydroxy- 4,6-dimethyl-7-oxo-2,4-heptadienamide;

MeSH Related Number : 58880-19-6 (trichostatin A);

Registry Number MeSH : 58880-19-6;

Is substance : O;

UNII : 3X2S926L3Z;

InChIKey : RTKIYFITIVXBLE-QEQCGCAPSA-N;

Details

Origin ID

C012589;

UMLS CUI

C0077063;

Automatic exact mappings (from CISMeF team)
- 300 (qualifier value) [SNOMED CT concept]
Currated CISMeF NLP mapping
- Trichostatin A [NCIt concept]
False automatic mappings
- Greece [NCIt concept]
MeSH term(s) associated for indexing
- hydroxamic acids [MeSH Descriptor]
Pharmacological action(s)
- antifungal agents [MeSH Descriptor]
- histone deacetylase inhibitors [MeSH Descriptor]
- protein synthesis inhibitors [MeSH Descriptor]
Record concept(s)
- A 300 [MeSH concept]
- trichostatin A [MeSH concept]
Semantic type(s)
- Antibiotic [UMLS semantic type]
- Organic Chemical [UMLS semantic type]
UMLS correspondences (same concept)
- Trichostatin A [NCIt concept]

Keyword's position in hierarchy(ies) :

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