Trichostatin A

Preferred Label : Trichostatin A;

NCIt related terms : (2E,4E,6R)-7-[4-(Dimethylamino)phenyl]-N-hydroxy-4,6-dimethyl-7-oxo-2,4-heptadienamide;

NCIt definition : A natural derivative of dienohydroxamic acid isolated from species of the bacterial genus Streptomyces. Trichostatin A (TSA) reversibly and specifically inhibits histone deacetylases, resulting in hyperacetylation of core histones which modulate chromatin structure. The increase in histone acetylation promotes selective gene transcription and the inhibition of tumor growth. This agent is a potent inducer of tumor cell growth arrest, differentiation and apoptosis in a variety of transformed cells in culture and in tumor-bearing animals. (NCI04);

UNII : 3X2S926L3Z;

InChIKey : RTKIYFITIVXBLE-QEQCGCAPSA-N;

CAS number : 58880-19-6;

Chemical formula : C17H22N2O3;

NSC code : 311042;

ChEBI ID : CHEBI:46024;

Codes from synonyms : 31914; NSC0311042;

Details

Origin ID

C1261;

UMLS CUI

C0077063;

Currated CISMeF NLP mapping
- trichostatin A [MeSH concept]
- trichostatin A [MeSH Supplementary Concept]
Semantic type(s)
- Antibiotic [UMLS semantic type]
- Organic Chemical [UMLS semantic type]
UMLS correspondences (same concept)
- trichostatin A [MeSH concept]
- trichostatin A [MeSH Supplementary Concept]
concept_is_in_subset
- FDA Established Names and Unique Ingredient Identifier Codes Terminology [NCIt concept]
- NCI Drug Dictionary Terminology [NCIt concept]

Keyword's position in hierarchy(ies) :

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