unfolded protein response

Preferred Label : unfolded protein response;

MeSH definition : A cellular response to environmental insults that cause disruptions in PROTEIN FOLDING and/or accumulation of defectively folded protein in the ENDOPLASMIC RETICULUM. It consists of a group of regulatory cascades that are triggered as a response to altered levels of calcium and/or the redox state of the endoplasmic reticulum. Persistent activation of the unfolded protein response leads to the induction of APOPTOSIS.;

MeSH synonym : response, unfolded protein; unfolded protein responses; protein response, unfolded; protein responses, unfolded; responses, unfolded protein;

Details

Origin ID

D056811;

UMLS CUI

C1155342;

Allowable qualifiers
- drug effects [MeSH Qualifier]
- genetics [MeSH Qualifier]
- immunology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Unfolded Protein Response [NCIt concept]
- response to unfolded protein [GO term]
Record concept(s)
- unfolded protein response [MeSH concept]
See also
- endoplasmic Reticulum-Associated degradation [MeSH Descriptor]
- endoplasmic reticulum stress [MeSH Descriptor]
- protein unfolding [MeSH Descriptor]
Semantic type(s)
- Cell Function [UMLS semantic type]
UMLS correspondences (same concept)
- Unfolded Protein Response [NCIt concept]
- cellular response to unfolded protein [GO term]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients