MeSH definition : Integral membrane protein of Golgi and endoplasmic reticulum. Its homodimer is an
essential component of the gamma-secretase complex that catalyzes the cleavage of
membrane proteins such as NOTCH RECEPTORS and AMYLOID BETA-PEPTIDES precursors. PSEN2
mutations cause ALZHEIMER DISEASE type 4.;
Integral membrane protein of Golgi and endoplasmic reticulum. Its homodimer is an
essential component of the gamma-secretase complex that catalyzes the cleavage of
membrane proteins such as NOTCH RECEPTORS and AMYLOID BETA-PEPTIDES precursors. PSEN2
mutations cause ALZHEIMER DISEASE type 4.