janus kinase 2

Preferred Label : janus kinase 2;

MeSH definition : A Janus kinase subtype that is involved in signaling from GROWTH HORMONE RECEPTORS; PROLACTIN RECEPTORS; and a variety of CYTOKINE RECEPTORS such as ERYTHROPOIETIN RECEPTORS and INTERLEUKIN RECEPTORS. Dysregulation of Janus kinase 2 due to GENETIC TRANSLOCATIONS have been associated with a variety of MYELOPROLIFERATIVE DISORDERS.;

MeSH synonym : jak 2 protein tyrosine kinase; JAK2 Protein Tyrosine Kinase; JAK-2 Protein Tyrosine Kinase;

CISMeF synonym : EC 2.7.1.112;

Registry Number MeSH : EC 2.7.10.1; EC 2.7.10.2;

Wikipedia link : https://en.wikipedia.org/wiki/Janus kinase 2;

Is substance : O;

UNII : EC 2.7.10.2;

Details

Origin ID

D053614;

UMLS CUI

C0169661;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Wee1-Like Protein Kinase [NCIt concept]
CISMeF manual mappings
- JAK2 Inhibitor [NCIt concept]
Indexing information
- 11-(2-pyrrolidin-1-ylethoxy)-14,19-dioxa-5,7,26-triazatetracyclo(19.3.1.1(2,6).1(8,12))heptacosa-1(25),2(26),3,5,8,10,12(27),16,21,23-decaene [MeSH Supplementary Concept]
- 14-methyl-20-oxa-5,7,14,26-tetraazatetracyclo(19.3.1.1(2,6).1(8,12))heptacosa-1(25),2(26),3,5,8(27),9,11,16,21,23-decaene [MeSH Supplementary Concept]
- 15-(2-(pyrrolidin-1-yl)ethoxy)-7,12,25-trioxa-19,21,24-triazatetracyclo(18.3.1.1(2,5).1(14,18))hexacosa-1(24),2,4,9,14(26),15,17,20,22-nonaene [MeSH Supplementary Concept]
- 5-fluoro-2-(1-(4-fluorophenyl)ethylamino)-6-(5-methyl-1H-pyrazol-3-ylamino)nicotinonitrile [MeSH Supplementary Concept]
- 7-(2-aminopyrimidin-5-yl)-1-((1-cyclopropyl-2,2,2-trifluoroethyl)amino)-5H-pyrido(4,3-b)indole-4-carboxamide [MeSH Supplementary Concept]
- AZD 1480 [MeSH Supplementary Concept]
- CEP 33779 [MeSH Supplementary Concept]
- LY2784544 [MeSH Supplementary Concept]
- N,N-dicyclopropyl-4-((1,5-dimethyl-1H-pyrazol-3-yl)amino)-6-ethyl-1-methyl-1,6-dihydroimidazo(4,5-d)pyrrolo(2,3b)pyridine-7-carboxamide [MeSH Supplementary Concept]
- XL019 compound [MeSH Supplementary Concept]
- preGc1f1fMAF protein, human [MeSH Supplementary Concept]
Record concept(s)
- janus kinase 2 [MeSH concept]
Related MeSH Supplementary Concept(s)
- JAK2 protein, human [MeSH Supplementary Concept]
- Jak2 protein, mouse [MeSH Supplementary Concept]
- Jak2 protein, rat [MeSH Supplementary Concept]
- TEL-JAK2 fusion protein, human [MeSH Supplementary Concept]
- TEL-JAK2 fusion protein, mouse [MeSH Supplementary Concept]
See also
- src homology domains [MeSH Descriptor]
See also inter- (CISMeF)
- Janus kinase 2 [ORDO Gene]
- Janus kinase 2 [OMIM gene]
- Janus kinase 2 [HGNC gene]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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