apoptotic Protease-Activating factor 1

Preferred Label : apoptotic Protease-Activating factor 1;

MeSH definition : A CARD signaling adaptor protein that plays a role in the mitochondria-stimulated apoptosis (APOPTOSIS, INTRINSIC PATHWAY). It binds to CYTOCHROME C in the CYTOSOL to form an APOPTOSOMAL PROTEIN COMPLEX and activates INITIATOR CASPASES such as CASPASE 9.; A CARD signaling adaptor protein characterized by an N-terminal CARD DOMAIN and C-terminal WD40 REPEATS. It plays a role in the mitochondria-stimulated apoptosis (APOPTOSIS, INTRINSIC PATHWAY) and binds to CYTOCHROME C in the CYTOSOL to form an APOPTOSOMAL PROTEIN COMPLEX which activates INITIATOR CASPASES such as CASPASE 9.;

MeSH synonym : apaf 1 protease activating factor; apaf-1 protease-activating factor; protease-activating factor, apaf-1; apoptotic protease activating factor 1; Apoptotic Peptidase Activating Factor 1;

Is substance : O;

Details

Origin ID

D053477;

UMLS CUI

C0664613;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- agonists [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
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- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Currated CISMeF NLP mapping
- Apoptotic Protease-Activating Factor 1 [NCIt concept]
Indexing information
- Ced-4 protein, C elegans [MeSH Supplementary Concept]
Record concept(s)
- apoptotic Protease-Activating factor 1 [MeSH concept]
Related MeSH Supplementary Concept(s)
- APAF1 protein, human [MeSH Supplementary Concept]
- Apaf1 protein, mouse [MeSH Supplementary Concept]
- Apaf1 protein, rat [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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