protein kinase c-alpha

Preferred Label : protein kinase c-alpha;

MeSH definition : A cytoplasmic serine threonine kinase involved in regulating CELL DIFFERENTIATION and CELLULAR PROLIFERATION. Overexpression of this enzyme has been shown to promote PHOSPHORYLATION of BCL-2 PROTO-ONCOGENE PROTEINS and chemoresistance in human acute leukemia cells.;

MeSH synonym : pkc alpha serine threonine kinase; protein kinase c(alpha); pkc-alpha serine-threonine kinase; serine-threonine kinase, pkc-alpha; protein kinase C alpha;

CISMeF synonym : EC 2.7.1.37;

Registry Number MeSH : EC 2.7.11.13;

Is substance : O;

UNII : EC 2.7.11.13;

Details

Origin ID

D051571;

UMLS CUI

C0256371;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- Protein Kinase C [NCIt concept]
- Protein Kinase C Alpha Type [NCIt concept]
- Protein kinase C, alpha [OMIM gene]
- Serine/Threonine-Protein Kinase D1 [NCIt concept]
- Serine/Threonine-Protein Kinase D2 [NCIt concept]
- Serine/Threonine-Protein Kinase D3 [NCIt concept]
- cAMP-Dependent Protein Kinase Catalytic Subunit Alpha [NCIt concept]
- protein kinase C alpha [HGNC gene]
Indexing information
- bisindolylmaleimide III [MeSH Supplementary Concept]
- poliumoside [MeSH Supplementary Concept]
Record concept(s)
- protein kinase C-alpha [MeSH concept]
Related MeSH Supplementary Concept(s)
- PRKCA protein, human [MeSH Supplementary Concept]
- prkca protein, mouse [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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