Cyclin-Dependent kinase 4

Preferred Label : Cyclin-Dependent kinase 4;

MeSH definition : Cyclin-dependent kinase 4 is a key regulator of G1 PHASE of the CELL CYCLE. It partners with CYCLIN D to phosphorylate RETINOBLASTOMA PROTEIN. CDK4 activity is inhibited by CYCLIN-DEPENDENT KINASE INHIBITOR P16.;

MeSH synonym : cdk4 cyclin dependent kinase; cdk4 protein; cdk4 protein kinase; cyclin d-dependent kinase cdk4; protein kinase, cdk4; psk j3 kinase; psk-j3 kinase; p34psk j3 kinase; p34psk-j3 kinase; cell division protein kinase 4; cyclin d dependent kinase cdk4; cdk4 cyclin-dependent kinase; cyclin-dependent kinase, cdk4; cyclin dependent kinase 4;

CISMeF synonym : EC 2.7.1.37;

Registry Number MeSH : EC 2.7.11.22;

Wikipedia link : https://en.wikipedia.org/wiki/Cyclin-dependent kinase 4;

Is substance : O;

UNII : EC 2.7.11.22;

Details

Origin ID

D051358;

UMLS CUI

C0246957;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- antagonists and inhibitors [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Currated CISMeF NLP mapping
- Cyclin-Dependent Kinase 4 [NCIt concept]
Indexing information
- 2-bromo-12,13-dihydro-5-indolo(2,3-a)pyrrolo(3,4-c)carbazole-5,7(6H)-dione [MeSH Supplementary Concept]
- 8-cyclopentyl-2-(4-(4-methylpiperazin-1-yl)phenylamino)-7-oxo-7,8-dihydropyrido(2,3-d)pyrimidine-6-carbonitrile [MeSH Supplementary Concept]
- CA 224 [MeSH Supplementary Concept]
- N-((5-(3-(4,6-difluoro-1H-benzimidazol-2-yl)-1H-indazol-5-yl)-4-methylpyridin-3-yl)methyl)ethanamine [MeSH Supplementary Concept]
Record concept(s)
- Cyclin-Dependent kinase 4 [MeSH concept]
Related MeSH Supplementary Concept(s)
- CDK4 protein, human [MeSH Supplementary Concept]
- Cdk4 protein, drosophila [MeSH Supplementary Concept]
- Cdk4 protein, mouse [MeSH Supplementary Concept]
- Cdk4 protein, rat [MeSH Supplementary Concept]
- Cdk4 protein, xenopus [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Enzyme [UMLS semantic type]
- Immunologic Factor [UMLS semantic type]
UMLS correspondences (same concept)
- Cyclin-dependent kinase 4 [LOINC component]

Keyword's position in hierarchy(ies) :

You can consult :

recommendations
documents concerning education
documents for patients