MeSH definition : A family of transcription factors that bind to the cofactor CORE BINDING FACTOR BETA
SUBUNIT to form core binding factor. Family members contain a highly conserved DNA-binding
domain known as the runt domain. They can act as both activators and repressors of
expression of GENES involved in CELL DIFFERENTIATION and CELL CYCLE progression.;
MeSH synonym : core binding factor alpha proteins; polyomavirus enhancer a binding protein 2; runt domain factor; transcription factors, pebp2a; runx proteins; polyomavirus enhancer binding protein 2, alpha subunit; acute myeloid leukemia proteins; pebp2a transcription factors;
A family of transcription factors that bind to the cofactor CORE BINDING FACTOR BETA
SUBUNIT to form core binding factor. Family members contain a highly conserved DNA-binding
domain known as the runt domain. They can act as both activators and repressors of
expression of GENES involved in CELL DIFFERENTIATION and CELL CYCLE progression.