calcium channels, L-Type

Preferred Label : calcium channels, L-Type;

MeSH definition : Long-lasting voltage-gated CALCIUM CHANNELS found in both excitable and nonexcitable tissue. They are responsible for normal myocardial and vascular smooth muscle contractility. Five subunits (alpha-1, alpha-2, beta, gamma, and delta) make up the L-type channel. The alpha-1 subunit is the binding site for calcium-based antagonists. Dihydropyridine-based calcium antagonists are used as markers for these binding sites.; Long-lasting voltage-gated CALCIUM CHANNELS found in both excitable and non-excitable tissue. They are responsible for normal myocardial and vascular smooth muscle contractility. Five subunits (alpha-1, alpha-2, beta, gamma, and delta) make up the L-type channel. The alpha-1 subunit is the binding site for calcium-based antagonists. Dihydropyridine-based calcium antagonists are used as markers for these binding sites.;

MeSH synonym : calcium channel, l-type; calcium channels, long-lasting; l type calcium channels; l type vdcc; l type voltage dependent calcium channels; l-type vdcc; vdcc, l-type; l-type calcium channel; l type calcium channel; l-type voltage-dependent calcium channels; l-type calcium channels; long-lasting calcium channels; long lasting calcium channels; calcium channels, L type; L-Type Voltage-Dependent Calcium Channel; L Type Voltage Dependent Calcium Channel; Long-Lasting Calcium Channel; Calcium Channel, Long-Lasting; Channel, Long-Lasting Calcium; Long Lasting Calcium Channel;

MeSH hyponym : receptors, dihydropyridine; L-Type VDCC beta subunit; L-Type VDCC gamma subunit; L-Type VDCC delta subunit; L-Type VDCC alpha-2 subunit; L-Type VDCC alpha-1 Subunit; L Type VDCC alpha 1 Subunit; Dihydropyridine Receptor; Receptor, Dihydropyridine; Dihydropyridine Receptors; L Type VDCC delta Subunit; L Type VDCC alpha 2 Subunit; L Type VDCC beta Subunit; L Type VDCC gamma Subunit;

MeSH annotation : DF: VDCC L;

Wikipedia link : https://en.wikipedia.org/wiki/Calcium channels, l-type;

Is substance : O;

Details

Origin ID

D020746;

UMLS CUI

C0288263;

Allowable qualifiers
- administration and dosage [MeSH Qualifier]
- adverse effects [MeSH Qualifier]
- analysis [MeSH Qualifier]
- biosynthesis [MeSH Qualifier]
- blood [MeSH Qualifier]
- cerebrospinal fluid [MeSH Qualifier]
- chemical synthesis [MeSH Qualifier]
- chemistry [MeSH Qualifier]
- classification [MeSH Qualifier]
- contraindications [MeSH Qualifier]
- deficiency [MeSH Qualifier]
- drug effects [MeSH Qualifier]
- economics [MeSH Qualifier]
- genetics [MeSH Qualifier]
- history [MeSH Qualifier]
- immunology [MeSH Qualifier]
- isolation and purification [MeSH Qualifier]
- metabolism [MeSH Qualifier]
- pharmacokinetics [MeSH Qualifier]
- pharmacology [MeSH Qualifier]
- physiology [MeSH Qualifier]
- poisoning [MeSH Qualifier]
- radiation effects [MeSH Qualifier]
- standards [MeSH Qualifier]
- supply and distribution [MeSH Qualifier]
- therapeutic use [MeSH Qualifier]
- toxicity [MeSH Qualifier]
- ultrastructure [MeSH Qualifier]
- urine [MeSH Qualifier]
Automatic exact mappings (from CISMeF team)
- DPYD wt Allele [NCIt concept]
- Dihydropyridine receptor [FMA entity]
- high voltage-gated calcium channel activity [GO term]
Indexing information
- 1-((4-chlorophenyl)sulfonyl)-2-(2-thienyl)pyrrolidine [MeSH Supplementary Concept]
- 2,5-dihydroxymethyl-3,6-dimethylpyrazine [MeSH Supplementary Concept]
Record concept(s)
- L-Type VDCC alpha-2 subunit [MeSH concept]
- L-Type VDCC beta subunit [MeSH concept]
- L-Type VDCC delta subunit [MeSH concept]
- L-Type VDCC gamma subunit [MeSH concept]
- calcium channels, L-Type [MeSH concept]
- receptors, dihydropyridine [MeSH concept]
Related MeSH Supplementary Concept(s)
- AID-TAT peptide [MeSH Supplementary Concept]
- CACNA1C protein, human [MeSH Supplementary Concept]
- CACNA1C protein, mouse [MeSH Supplementary Concept]
- CACNA1D protein, human [MeSH Supplementary Concept]
- CACNA1F protein, human [MeSH Supplementary Concept]
- CACNA1S protein, human [MeSH Supplementary Concept]
- CACNA1S protein, mouse [MeSH Supplementary Concept]
- CACNA2D4 protein, human [MeSH Supplementary Concept]
- CACNB1 protein, zebrafish [MeSH Supplementary Concept]
- CACNB2 protein, human [MeSH Supplementary Concept]
- Cacna1c protein, rat [MeSH Supplementary Concept]
- Cacna1d protein, mouse [MeSH Supplementary Concept]
- Cacna1f protein, mouse [MeSH Supplementary Concept]
- Cacna2d1 protein, rat [MeSH Supplementary Concept]
- Cacna2d4 protein, mouse [MeSH Supplementary Concept]
- Cacnb1 protein, mouse [MeSH Supplementary Concept]
- Cacnb2 protein, mouse [MeSH Supplementary Concept]
- Cacnb2 protein, rat [MeSH Supplementary Concept]
- L-type calcium channel alpha(1C) [MeSH Supplementary Concept]
- cacna1da protein, zebrafish [MeSH Supplementary Concept]
- cacna1fb protein, zebrafish [MeSH Supplementary Concept]
- cacnb2a protein, zebrafish [MeSH Supplementary Concept]
- calcium channel, l type beta2c subunit, rat [MeSH Supplementary Concept]
- dihydropyridine receptor (671-690) [MeSH Supplementary Concept]
Semantic type(s)
- Amino Acid, Peptide, or Protein [UMLS semantic type]
- Biologically Active Substance [UMLS semantic type]

Keyword's position in hierarchy(ies) :

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