Preferred Label : mptp poisoning;
MeSH definition : A condition caused by the neurotoxin MPTP which causes selective destruction of nigrostriatal
dopaminergic neurons. Clinical features include irreversible parkinsonian signs including
rigidity and bradykinesia (PARKINSON DISEASE, SECONDARY). MPTP toxicity is also used
as an animal model for the study of PARKINSON DISEASE. (Adams et al., Principles of
Neurology, 6th ed, p1072; Neurology 1986 Feb;36(2):250-8);
MeSH synonym : mptp neurotoxicity syndrome; mptp neurotoxicity syndromes; parkinsonism, mptp-induced; poisoning, mptp; poisoning, 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine; neurotoxicity syndrome, mptp; neurotoxicity syndromes, mptp; mptp-induced parkinsonism; mptp induced parkinsonism;
MeSH hyponym : MPTP-Induced degeneration of the striatum; MPTP Induced Degeneration of the Striatum;
MeSH annotation : not for animal models of Parkinson disease induced by MPTP: index MPTP-INDUCED EXPERIMENTAL
PARKINSONISM;
Origin ID : D020267;
UMLS CUI : C0270730;
Allowable qualifiers
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- See also (suggested by CISMeF)
- Semantic type(s)
- UMLS correspondences (same concept)
A condition caused by the neurotoxin MPTP which causes selective destruction of nigrostriatal
dopaminergic neurons. Clinical features include irreversible parkinsonian signs including
rigidity and bradykinesia (PARKINSON DISEASE, SECONDARY). MPTP toxicity is also used
as an animal model for the study of PARKINSON DISEASE. (Adams et al., Principles of
Neurology, 6th ed, p1072; Neurology 1986 Feb;36(2):250-8)
