Preferred Label : 1-Methyl-4-phenylpyridinium;
MeSH definition : An active neurotoxic metabolite of 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE. The
compound reduces dopamine levels, inhibits the biosynthesis of catecholamines, depletes
cardiac norepinephrine and inactivates tyrosine hydroxylase. These and other toxic
effects lead to cessation of oxidative phosphorylation, ATP depletion, and cell death.
The compound, which is related to PARAQUAT, has also been used as an herbicide.;
MeSH synonym : 1 methyl 4 phenylpyridine; n-methyl-4-phenylpyridinium; 1 methyl 4 phenylpyridinium ion; n-methyl-4-phenylpyridine; cyperquat; n methyl 4 phenylpyridine; 1-methyl-4-phenylpyridine; 1-methyl-4-phenylpyridinium ion; 1 methyl 4 phenylpyridinium;
CISMeF synonym : 39794-99-5 (1-Methyl-4-phenylpyridinium chloride);
MeSH hyponym : 1-Methyl-4-phenylpyridinium chloride; 1 Methyl 4 phenylpyridinium Chloride;
MeSH CAS label : pyridinium, 1-methyl-4-phenyl-;
MeSH Related Number : 1-Methyl-4-phenylpyridinium chloride; 39794-99-5 (chloride); 48134-75-4 (1-Methyl-4-phenylpyridinium); MRP3DNB9K9;
Registry Number MeSH : 48134-75-4;
Related CAS MeSH : MRP3DNB9K9 (1-Methyl-4-phenylpyridinium chloride);
Is substance : O;
UNII : R865A5OY8J;
InChIKey : FMGYKKMPNATWHP-UHFFFAOYSA-N;
Origin ID : D015655;
UMLS CUI : C0000098;
Allowable qualifiers
- CISMeF manual mappings
- Pharmacological action(s)
- Record concept(s)
- Related MeSH Supplementary Concept(s)
- See also
- Semantic type(s)
- UMLS correspondences (same concept)
An active neurotoxic metabolite of 1-METHYL-4-PHENYL-1,2,3,6-TETRAHYDROPYRIDINE. The
compound reduces dopamine levels, inhibits the biosynthesis of catecholamines, depletes
cardiac norepinephrine and inactivates tyrosine hydroxylase. These and other toxic
effects lead to cessation of oxidative phosphorylation, ATP depletion, and cell death.
The compound, which is related to PARAQUAT, has also been used as an herbicide.
